In Vitro ADME Studies

Our in vivo ADME studies investigate how compounds are absorbed, distributed, metabolized, and excreted within living systems. These studies provide essential information on drug disposition and help bridge the gap between laboratory findings and physiological outcomes.

In vivo ADME studies provide critical insights into the biological fate of compounds and support the development of safer and more effective therapeutics.

In Vivo ADME Studies

Our in vivo ADME studies investigate how compounds are absorbed, distributed, metabolized, and excreted within living systems. These studies provide essential information on drug disposition and help bridge the gap between laboratory findings and physiological outcomes.

In vivo ADME studies provide critical insights into the biological fate of compounds and support the development of safer and more effective therapeutics.

In Vivo Pharmacokinetic Studies

Our in vivo pharmacokinetic studies evaluate the concentration-time profile of compounds within biological systems. These studies generate quantitative data on drug exposure, clearance, bioavailability, and dosing characteristics to support therapeutic development.

In vivo pharmacokinetic studies are essential for understanding drug exposure and supporting informed decision-making throughout the drug development process.

Clinical Toxicology

Our clinical toxicology services focus on evaluating toxicological risks associated with therapeutic compounds, environmental agents, and xenobiotics. We support both research and clinical investigations aimed at understanding adverse biological effects and improving patient safety.Our clinical toxicology services focus on evaluating toxicological risks associated with therapeutic compounds, environmental agents, and xenobiotics. We support both research and clinical investigations aimed at understanding adverse biological effects and improving patient safety.

Our toxicology services support evidence-based safety evaluation during drug development and translational research.

Validated Assays

• Kinetic Solubility Assay

  Kinetic solubility studies are essential in determining the aqueous solubility behavior of compounds under physiologically relevant conditions. Poor solubility remains one of the major causes of attrition during drug development.

• Log D7.4 Assay

  The Log D7.4 assay evaluates compound partitioning between aqueous and organic phases at physiological pH. Lipophilicity strongly influences membrane permeability, absorption, tissue distribution, and metabolic stability.

• Plasma Protein Binding Assay

  Plasma protein binding studies evaluate the extent to which compounds bind to plasma proteins. Only the unbound fraction of a drug is pharmacologically active and available for distribution and elimination.

• Microsomal Stability Assay

  Microsomal stability assays assess the metabolic susceptibility of compounds using liver microsomes from different species. These studies help predict hepatic clearance and metabolic behavior in vivo.

• Plasma Stability Assay

  Plasma stability studies determine the chemical and enzymatic stability of compounds in plasma matrices. These studies are important for identifying degradation liabilities that may affect pharmacokinetic performance.

• Permeability Assay (PAMPA)

  The Parallel Artificial Membrane Permeability Assay (PAMPA) is used to estimate passive diffusion across biological membranes. The assay provides valuable insight into intestinal absorption and blood-brain barrier penetration potential.

• Chemical Stability Assay

  Chemical stability studies assess the degradation profile of compounds under defined environmental and experimental conditions. Stability information is critical for formulation, storage, and pharmacokinetic interpretation.